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The Autonomic Nervous System

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While sobering, these figures are perhaps unsurprising since there is now one new case of dementia diagnosed every 4 s, or 77 million cases per year (2). More than 300 million people are now living with depression, an increase of more than 18% between 2005 and 2015. The parasympathetic nervous system (PNS) controls homeostasis and the body at rest and is responsible for the body's 'rest and digest' function. The sympathetic nervous system (SNS) controls the body's responses to a perceived threat and is responsible for the 'fight or flight' response. The PNS and SNS are part of the autonomic nervous system (ANS), which is responsible for the involuntary.

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The autonomic nervous system (ANS) regulates visceral functions, i.e. functions of the internal organs such as the heart, stomach and intestines. The ANS is part of the peripheral nervous system and also has control over some muscles within the body. The functions of the ANS are involuntary and reflexive, e.g. the beating of the heart, expansion or contraction of blood vessels or pupils, etc. — which is why we are seldom conscious of it. The parasympathetic and sympathetic nervous systems, along with the enteric nervous system make up the ANS.

What is the parasympathetic nervous system?

The parasympathetic nervous system is part of the autonomic nervous system. It originates in the spinal cord and the medulla and controls homeostasis, or the maintenance of the body's systems. The parasympathetic nervous system controls the 'rest and digest' functions of the body.

What is the sympathetic nervous system?

The sympathetic nervous system, also part of the autonomic nervous system, originates in the spinal cord; specifically in the thoracic and lumbar regions. It controls the body's 'fight or flight' responses, or how the body reacts to perceived danger.

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Sympathetic vs Parasympathetic Responses

With sympathetic nervous responses, the body speeds up, tenses up and becomes more alert. Functions that are not essential for survival are shut down. Following are the specific reactions of sympathetic nervous system:

  • increase in the rate and constriction of the heart
  • dilation of bronchial tubes in the lungs and pupils in the eyes
  • contraction of muscles
  • release of adrenaline from the adrenal gland
  • conversion of glycogen to glucose to provide energy for the muscles.
  • shut down of processes not critical for survival
  • decrease in saliva production: the stomach does not move for digestion, nor does it release digestive secretions.
  • decrease in urinary output
  • sphincter contraction.
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The parasympathetic nervous system counterbalances the sympathetic nervous system. It restores the body to a state of calm. The specific responses are:

  • decrease in heart rate
  • constriction of bronchial tubes in the lungs and pupils in the eyes
  • relaxation of muscles
  • saliva production: the stomach moves and increases secretions for digestion.
  • increase in urinary output
  • sphincter relaxation.
A diagram of parasympathetic and sympathetic effects. Click to enlarge.

How it Works

The parasympathetic nervous system is a slower system and moves along longer pathways. Preganglionic fibers from the medulla or spinal cord project ganglia close to the target organ. They create a synapse, which eventually creates the desired response.

The sympathetic nervous system is a faster system as it moves along very short neurons. When the system is activated, it activates the adrenal medulla to release hormones and chemical receptors into the bloodstreams. The target glands and muscles get activated. Once the perceived danger is gone, the parasympathetic nervous system takes over to counterbalance the effects of the sympathetic nervous system's responses.

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References

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PNS - Image 1:
Artist illustration of the connective tissue associated with a peripheral nerve. Nerves are composed of nerve fascicles. The entire nerve is enveloped by connective tissue called epineurium. Individual fascicles are delineated by perineurium. Layers of flattened mesodermal cells, called perineural epithelium (epithelioid) cells, line the perineurium. Connective tissue inside perineural epithelium is called endoneurium.
PNS - Image 2:
ransverse section through a nerve fascicle (Wolter myelin stain). Myelin sheaths (red arrows) are stained black. Because of lipid composition, perineural epithelium (green arrows) stains slightly.
PNS - Image 3:
Transverse section through a peripheral nerve (Triple stain). Several nerve fascicles are visible. Each fascicle is surrounded by perineural epithelium (red arrows). Fibrous perineurium (yellow arrows) is outside of the perineural epithelium.
PNS - Image 4:
High power view of the margin of a nerve fascicle (silver stain). Non-myelinated axons (non.a) appear as clusters of dots. Myelinated axons (my.a) are each surrounded by myelin sheath (m). The fascicle is delineated by perineural epithelium (pe) inside fibrous perineurium (p).
PNS - Image 5:
High power view of the margin of a nerve fascicle (Triple stain). Myelinated axons (a) are each surrounded by myelin sheath (m). Blue endoneurium (e) is evident within the fascicle. The nerve fascicle is delineated by perineural epithelium (pe) inside fibrous perineurium (p).
PNS - Image 6:
Transverse section through myelinated fibers within a nerve fascicle (Triple stain). Blue endoneurium surrounds myelin sheaths. Myelin neurokeratin appears as well defined red circles.
PNS - Image 7:
Transverse section through myelinated fibers within a nerve fascicle (Triple stain), a higher power view of the preceding section. Blue endoneurium surrounds myelin sheaths. Myelin neurokeratin appears as well defined red circles. Axons (asterisks) within myelin rings generally are not distinct with this stain.
PNS - Image 8:
Transverse section through myelinated fibers of a ventral root (silver stain). Axons are distinct within myelin sheaths (neurokertatin). Ventral roots are are covered by meninges (pia mater).
PNS - Image 9:
Longitudinal section through myelinated fibers within a nerve fascicle (Triple stain). An axon (asterisk) and a myelin node (arrow) are labeled. Myelin neurokeratin is red. Endoneurium is blue.
PNS - Image 10:
High power view of a longitudinal section through a nerve fascicle. An axon (red arrow) and two myelin nodes (green arrows) are labeled. Myelin neurokeratin is indicated by red asterisks. Lemmocyte cell nuclei are labeled with black arrows.
PNS - Image 11:
Longitudinal section through part of a spinal ganglion (Triple stain). Unipolar cell bodies (N) can be seen superficial to dorsal root nerve fibers (myelinated fibers) and deep to epineurium of a spinal nerve. Each cell body has a central nucleus and is surrounded by a well-defined capsule of satellite glial cells (arrows).
PNS - Image 12:
Section through part of an autonomic ganglion (Triple stain). Multipolar neuron cell bodies (N) are within poorly-defined capsules formed by satellite glial cells (arrows).
PNS - Image 13:
High power view of a section through part of an autonomic ganglion (Triple stain). Multipolar neuron cell bodies with eccentric nuclei (white arrows) are within poorly-defined capsules formed by satellite glial cells (red arrows). Axons (green arrows) can be seen leaving cell bodies.
PNS - Image 14:
Schematic illustration of receptors. Free nerve endings (upper left) are shown extending into the epidermis. Tactile corpuscles (lower left) involve epidermal cells transformed into sensory cells by nerve endings. Encapsulated receptors (right) consist of nerve endings encapsulated by lemmocytes and perineural epithelium.
PNS - Image 15:
Pacinian (lamellar ) corpuscle. Left: Schematic illustration of a lamellar corpuscle sectioned longitudinally. The axon (yellow) is surrounded immediately by lemmocytes, in turn surrounded by perineural epithelium. The red arrow points to a transection at the level indicated. Right: Transverse section through an actual Pacinian corpuscle.
PNS - Image 16:
Transverse section through a Pacinian (lamellar ) corpuscle from a feline urethra (Triple stain). The axon (arrow) is surrounded immediately by lemmocytes which, in turn, are surrounded by perineural epithelium.