abstract
- Large-conductance calcium-activated potassium channels (maxi-K channels) have an essential role in the control of excitability and secretion. Only one gene Slo is known to encode maxi-K channels, which are sensitive to both membrane potential and intracellular calcium. We have isolated a potassium channel gene called Slack that is abundantly expressed in the nervous system. Slack channels rectify outwardly with a unitary conductance of about 25-65 pS and are inhibited by intracellular calcium. However, when Slack is co-expressed with Slo, channels with pharmacological properties and single-channel conductances that do not match either Slack or Slo are formed. The Slack/Slo channels have intermediate conductances of about 60-180 pS and are activated by cytoplasmic calcium. Our findings indicate that some intermediate-conductance channels in the nervous system may result from an interaction between Slack and Slo channel subunits.
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The Cornell Concert Series is excited to partner with ONEcomposer to share their recent collaborations with soprano Karen Slack, a star of the international opera stage; and Babson College, whose entrepreneurship program is ranked number one in the country by U.S. News and World Report. Katie Slack, CPA, CFE, CHFP Assistant Controller at Weill Cornell Medicine New York, New York 186 connections.
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